Immunization Data & Decision Making unit
The Immunization Data & Decision Making (DDM) unit collects, collates, analyzes and produces core annual insights on global immunization system performance. These data are critical for ensuring performance accountability of bodies such as WHO, UNICEF, The Gavi Alliance and others.
COVID-19 Vaccine Effectiveness
WHO guidance on conducting COVID-19 VE evaluations
Second addendum to Evaluation of COVID-19 vaccine effectiveness: Interim guidance
23 July 2021
Guidance on conducting vaccine effectiveness evaluations in the setting of new SARS-CoV-2...
Interim guidance
Tools to assist conducting studies
Sample size calculator for conducting a test-negative design study(Source: I-MOVE-COVID-19 Network)
Presentation on integrating genetic sequencing information into VE analyses (Source: I-MOVE-COVID-19 Network)
Data collection tool for linking epidemiologic and sequencing data, including sampling fraction (Source: I-MOVE-COVID-19 Network)
R script for calculating a crude vaccine effectiveness and confidence intervals using the screening method
(Source: US CDC Zipped file)
Protocols
The following protocols can be used to conduct a VE evaluation, though might need to be modified based on the context in which the study is being done:
WHO protocols
Estimating COVID-19 vaccine effectiveness against severe acute respiratory infections (SARI) hospitalizations associated with laboratory-confirmed SARS-CoV-2
Generic protocol: a prospective cohort study investigating maternal, pregnancy and neonatal outcomes for women and neonates infected with SARS-CoV-2
Cohort study to measure COVID-19 vaccine effectiveness among health workers
Household transmission investigation protocol for 2019-novel coronavirus (COVID-19) infection
External protocols
WHO meeting reports on COVID-19 VE
Other relevant WHO material on VE studies